Editorial: what can be done when infliximab stops working in ulcerative colitis?

Infliximab in ulcerative colitis

Infliximab, a monoclonal anti-TNF-alpha antibody, is commonly used for treatment of moderate to severe Crohn's disease (CD). Its role in the treatment for ulcerative colitis (UC) remains controversial. We review the role of TNF-alpha in the pathogenesis of UC and describe the randomized, double-blind, placebo-controlled trials and systematic reviews that assess the efficacy of infliximab in the...

Infliximab in ulcerative colitis

This paper critically reviews the evidence for established (5-aminosalicylic acid [5-ASA] compounds, corticosteroids, immunomodulators, calcineurin inhibitors) and emerging novel therapies-including biological therapies-directed at cytokines (eg, infliximab, adalimumab, certolizumab pegol) and receptors (eg, visilizumab, abatacept) involved in T-cell activation, selective adhesion molecule bloc...

Inequality – What can be done ?

Prof. Atkinson is one of the most influential authors on inequality. This popular science book consists of 400 pages, divided in three parts: Diagnosis, Proposal for Action and Can It Be Done with 11 chapters. Beside these 11 chapters, there is an Introduction and the final part of the book entitled The Way Forward. At the end of the book, there is Glossary and a long list of the notes for each...

Public health in times of war and famine: what can be done? What should be done?

What can be done to reduce overconsumption?

Overconsumption of natural resources is frequently portrayed as a significant environmental threat. This paper addresses overconsumption from the individual level, discussing the problems associated with identifying overconsumption and identifying general approaches that can he used to reduce consumption. A behavioral approach to understanding resource consumption is presented, with the existin...